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Morpholino Summary
General Information
Morpholino name: nacre    
Morpholino sequence: 5'-CATGTTCAACTATGTGTTAGCTTCA-3'
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Target name: mitfa
Target sequence: (Morpholino Target and ATG)
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ACTGGTCAGTTCTTGCACATCACCTAAATTCACAAAGGGAATACTTTTTTGAAGCTAACACATAGTTGA ACATGTTGGAGATGCTCGAGTACAGTCACTACCAGGTTCAGACCCACCTGGAAACCCCCTCGAAGTACCA CATCCAGCAGAGCCAGAGGCAGCAGGTGAAGCACTACCTGTCCAGTGCACTAGGAGCCAAGCTGAGCCCA CAGGCCAGCACAGGGCCCGGCCCCAGCCAGCCCGCCGAGCACGGCATGACCCCGGGACCCGGAGCCAGCG CTCCCAACAGCCCTATGGCCCTTCTCACCCTCAACTGTGAGAAAGAGATGGACGATGTAATTGAAGACAT TATAAGTTTGGAATCAAGCTACAGTGATGACATTCTTGGGTTCATGGATGCAGGACTTCAAATGACAAAC ACGATTCCAGTTTCAGCAAACCTGCTGGACATGTACAGCAATCATGCTCTTCCTCCAGCTGGAGTTTCCA TCAGTAACTCCTGCCCCTCAAGCCTGCCGGCCGTCAAAAGGGAATTATCCGTTACTCCATCTCCGGGCAT GATGCACATAATGGACAAAGCTGGACCATGTGGCAAGTTTGACTCTTATCAAAGACCTGATGGCTTTCCA GTAGAAGCAGAAGTCAGAGCCCTGGCAAAAGAGAGACAAAAGAAGGACAACCACAACCTCATTGAACGAA GAAGGCGGTTTAATATCAATGACAGAATTAAGGAGCTGGGGACTTTAATTCCCAAGTCAAATGATCCAGA CATGAGGTGGAATAAAGGCACCATCCTGAAAGCATCAGTGGATTACATTAGGAAATTGCAGAAAGAGCAG CAGAAAGCAAAAGAGCTGGAAAACAGACAGAAGAGACTAGAACACGCAAACAGACATCTCCTGCTCCGTA TTCAGGAACTTGAAATGCAAGCCCGTGCTCATGGACTCACCGTTGTAGCTTCTTCCAGCCTTTATTCCGC TGAGTTAGTGGCTCGAGCAATCAAACAAGAGCCTGGGATGGGGGACTGCACATCCAATTTGTACCCACAC CTTCCCAGTCCTGACATGTCCCGTCCTACCACTCTGGACCTCAACAACGGCACCATCAGCTACAATGACA GTCCCACGGAGGACGGCGAGCCGGGGGTCTACGACAGCCCAAACAAGGCCTCCACCAAGCTGGAGGACAT GCTTATGGACAACACCCTGTCTCCGGTGGGCAGCAGCGACCCGCTGTTGTCCTCCGGATCCCCAGTACCT TCCAACAGTAGCGGCAGCAGCAGTATGGACGAACATGACAATGGCTGTTAGCAATGCCAACTAAATTTCA TGAACCAAAGTTAGACAATTAGATTTGTGTGTGTGTGTGTCTTGTAAGTACCAGTGTTACATCCAGATCA TGAAGAGCGCAATTTCGTAAAGTATTAATCTTGTATTTCAGAATATTTAGTGTGCTTGTGTATATATTTT TTCATTTATCATGTCAGAGTCTAGTCAAGAATGAAATCGTGTAAACAATTAGTTGATTTTTGAAGGATTC TCGCGGATGATATAAAGAGTAGCTTGAATAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAA
Gene targeted:
microphthalmia-associated transcription factor a
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All the morpholinos targets to the gene
Synonyms:
z3A.1, nacre, Mitf-related gene, nac
Comments:
Reference:

Survival Curve: Normality Curve:
Note: When more than one data point existed per dose an average was used. p53 morpholino co-injections were used to minimize non-specific toxicity effects (Robu et al. PLoS Genetics 2007)
Screens Performed (number of tests): Defects Observed:
Morphology: (6)
Blood: (2)
- trunk colorless
(80%, dose:6ng, p53:ng, days: -)
- trunk colorless
(50%, dose:9ng, p53:ng, days: -)

Images


Figure 1. Knockdown of nacre results in decreased in pigment