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Morpholino Summary
General Information
Morpholino name: SP1989 A    
Morpholino sequence: TTTGCCACGACCGACTGATTAAGTA
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Target name: tm9sf2
Target sequence: (Morpholino Target and ATG)
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GATGCTGCTACGCAGGCAGCGGTTACGCTAACGCTTGTGCTTAGACATCACCAATGTCTGAATTTTGAC ACCCATATCTACATTTCACGCATGTAAATACATCTACAGATTACTTAATCAGTCGGTCGTGGCAAAATGG TCGAGTTCCACCGTGTCCGTGTTGTATTTGTGTCGCTTTTCTTGTGCGGGTTGTTGCAGGACGCGTTGAG TTTCTATCTTCCTGGTTTGGCCCCGGTCAGCTTCTGTAAGAAAGAAGCGGGCGACAAAAACAGCGAAGTC CCAGACTGCAAGTCAACCATTGAGCTCTTTGTGAACAGGCTGGATTCTGTGGAGTCAGTTTTACCCTATG AATATACTGCGTTTGATTTTTGTGCTGAGCAACATGAGAAGCGTCCATCTGAGAACTTGGGCCAGGTGTT GTTTGGTGAGAGAATTGAGCTGTCCCCATATAAGTTTTTGTTCCAGAATGATTTGCAATGCCAGTCTGTC TGCGTCAAGTCTTACAAAACACAAGATGCAGGTGATAAAGCCAAATTGGATTTCCTCAAGAAGGGAATGC TCCTCAATTACCAACACCACTGGATTGTTGATAATATGCCGGTGACCTGGTGTTACGATGTGGGGGACAA TCAGAAGTTCTGTAATCCTGGCTTTCCCATTGGTTGTTATGTCACAGATACAGGACGGGCCAAAGATGCC TGTGTGGTCAATGCTGACTTCAATGACAAAGACACCTTCTACATCTTCAACCATGTGGACATAACAATTT TCTACCACAATGTGGAAAATGAGGTTGCTGGTGCCAGACTGGTTGCAGCTAAGTTAGAGCCCAAAAGCTT TAAGCAGTCCAACGTAGACAAACCAGACTGCACAGGACCTCCCATGAGCCTGAGCAACAAGTTCAATGGA GAAATCAGGATACCCTACACTTACTCTGTCAAGTTTCTGGAGGATAAGACAATTCGCTGGGCCTCCAGAT GGGATTACATTCTTGAGTCTATGCCACACACAAACATTCAGTGGTTCAGTATCATGAACTCTCTGGTCAT CGTACTCTTCCTCTCTGGAATGGTCGCTATGATCATGCTTCGAACACTTCATAAAGATATCGCTCGATAC AACCAGATGGACTCTGTGGAGGATGCACAGGAGGAATTTGGCAGGAAGCTGGTTCATGGAGATGTCTTCA GGCCGCCTAGGAAAGGCATGCTGCTGTCTGTGTTCCTTGGTTCTGGGACTCAGATCTTCATCATGACCTT TGTCACTCTATTTTTTGCCTGTTTGGGTTTCCTGTCACCTGCCAATCGCGGGGCTCTGATGACGTGTGCA GTGGTGCTGTGGGTGCTCTTGGGTACTCCAGCTGGTTATGTGGCTGCTCGCTACTACAAATCTTTCGGTG GTGAGAAGTGGAAGACCAATGTTCTGTTGACAGCTTTTCTCTGTCCAGGAGTGGTGTTTGCAGATTTCTT TGTGATGAATCTCATTTTGTGGGGTGAGGGTTCATCCGCTGCCATGCCCTTTGGCACTCTGGTTGCCATC CTGGCTCTGTGGTTTTGCATATCAGTGCCCCTCACCTTTATCGGAGCGTACTTCGGTTTCAAGAAAAGCG CCATTGAACATCCTGTGCGGACCAACCAGATTCCAAGACAGATTCCAGAGCAGTCCTTCTATACTAAACC TCTTCCTGGCATTGTCATGGGAGGAATCCTGCCATTCGGATGCATCTTCATCCAGCTGTTTTTCATTCTC AACAGCATCTGGTCTCACCAGATGTACTACATGTTTGGCTTTCTCTTCCTGGTCTTTATCATCTTGGTCA TCACCTGCTCTGAGGCCACCATTCTCCTCTGCTACTTCCACCTGTGTGCTGAGGACTATCACTGGCAGTG GCGTTCTTTCCTGACCAGCGGATTCACAGCTGTTTATTTCCTGGTCTATGCCATCCATTACTTCTTCTCT AAGCTGCAGATCAGCGGACTTGCCAGCACCATTCTTTACTTTGGTTACACCATGATCATGGCGCTCATCT TCTTCCTCTTCACAGGCACCATTGGATTCTTCGCTTGCTTTTGGTTTGTCACCAAGATCTACAGCGTGGT CAAAGTGGATTAAATGAAAGCAATCTCAGATGAGACTGAACTTCTCTTCTCCGCCCAATGTGAGATCCCA GAGGGAGGGACCTGAGCGCTGTTTATCTTCTGTTGCCACGGCAACCCTTCTTTACATCAGCAACTCTAAA TCTACAAATTTAATTTACTTTGCTGTGTGTGCGTGCGGGCGTGTGTACATTAGTAGTGCATATTCAACCA ATTGGAAGAACTCTACACATCTGCTTCTTTAGTTGGAACAGAATACAGCAGAAACACACATTGGCCCTTA TAACTCACATGGGTATTTACGATTTGGAGTTGTCATTTGTAAATATTACTTACTTTATTCTTTTGCTAAC GTTCAAATGGAAGGGTAATGCATAAATCGCAGAGAAAACTAGCTCCAGTCATTGAATCTTCAAGGTGTCG GAAGTATGATTTTGTAAATATCTTCTTTTGTTTCTTAAATTCATCAAGCAAGAAAGTAGAAGTTGAAAGC CGAAGGACTTCATTCTTTGGGTTGATTTAAGAGTGAGGCTGTGTGAATTTTCTTTTTTTCCATCTTGTTG ATACTGTACAATTACTGCTTGCGTATACTTGTGTATAACCAGTGGGGGGAATGTCTATTTAACTTTTTTG TTTGGTCATTTTTTCTTTGTTTTCTGTTTATGCCTCAACACTTTGTGTGCCTCATTATCACAGAGGAAAA TCAAGACTGGTAAAAACTGATTTGGGAAGATGTGAAGTGCCCCGTCCTTACACAGGGGTAACTGGAGTGA AATGATTTCTTTTGTTTGTATATATGCACAGCGTTAAACGTGTGTCCAGCATAAACTACATTAGCTTGGT TGGCTACTCGGTTTTGGTTTTTGTCTTCTCTGATTTTGAGGTAATGAGATTACAAGAAAAATGAAAAAAA AAAAACTATTAGAAATAAAACCTTGTCTTCAAAAATAAAAAAAAAAAAAAAAA
Gene targeted:
transmembrane 9 superfamily member 2
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All the morpholinos targets to the gene
Synonyms:
Comments:
Reference:

Survival Curve: Normality Curve:
Note: When more than one data point existed per dose an average was used. p53 morpholino co-injections were used to minimize non-specific toxicity effects (Robu et al. PLoS Genetics 2007)
Screens Performed (number of tests): Defects Observed:
Cranial Motor Neuron: (2)
Vasculature: (3)
Eye: (5)
- eye small size
(14.29%, dose:3ng, p53:ng, days: Day: 3)
- cardiovascular system decreased
(14.29%, dose:6ng, p53:0ng, days: -)

Images


Figure 1. Absence of midbrain hindbrain boundary.


Figure 2. Wild type midbrain hindbrain boundary.